LYMPHOID NEOPLASIA The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
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چکیده
Davide Rossi,1 Valeria Spina,1 Clara Deambrogi,1 Silvia Rasi,1 Luca Laurenti,2 Kostas Stamatopoulos,3 Luca Arcaini,4 Marco Lucioni,5 Gabrielle B. Rocque,6 Zijun Y. Xu-Monette,7 Carlo Visco,8 Julie Chang,6 Ekaterina Chigrinova,9 Francesco Forconi,10 Roberto Marasca,11 Caroline Besson,12 Theodora Papadaki,13 Marco Paulli,5 Luigi M. Larocca,14 Stefano A. Pileri,15 Valter Gattei,16 Francesco Bertoni,9 Robin Foà,17 Ken H. Young,7 and Gianluca Gaidano1
منابع مشابه
The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.
Richter syndrome (RS) represents the development of diffuse large B-cell lymphoma in the context of chronic lymphocytic leukemia. The scarcity of biologic information about RS has hampered the identification of molecular predictors of RS outcome. We addressed this issue by performing a comprehensive molecular characterization of 86 pathologically proven RS. TP53 disruption (47.1%) and c-MYC abn...
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Background: Chronic lymphocytic leukemia (CLL) can transform into fast growing lymphoma for diffuse large B-cell lymphoma (DLBCL) called Richter's syndrome (RS), which is commonly related to an existence of large B-cells with equal or larger size than macrophage nuclei or more than twice those of normal lymphocyte. We conducted a systematic review of the existing literature to assess the clinic...
متن کاملHodgkin's lymphoma as a unique variant of Richter syndrome.
progression in lymphadenopathy, the appearance/worsening of “B” symptoms, and elevated levels of lactate dehydrogenase, as well as histological features requiring a new tissue biopsy. The incidence of Richter syndrome in patients with CLL is 2% to 9%. Most frequently, CLL transforms into diffuse large B cell lymphoma, while in only 0.4% of patients will CLL transform to Hodgkin’s lymphoma [4]. ...
متن کاملRichter syndrome: chronic lymphocytic leukemia transformation into Hodgkin's disease.
r ichter syndrome is a clinical condition in which indolent chronic lymphocytic leukemia evolves into a more aggressive diffuse large B cell lymphoma. Maurice Nethaniel Richter first described this phenomenon in 1928, which was named the “Richter syndrome” in 1964 [1]. Due to the aggressive nature of the disorder, the clinical manifestations, prognosis and treatment differ from CLL1 [2]. Sympto...
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تاریخ انتشار 2011